INR RAS - innovations


1. Field of Application

Generators of rubidium-82 are intended for generation of radionuclide rubidium-82 which is used for non-invasive investigation of myocardial perfusion using the method of positron-emission tomography (PET) during the diagnostics and prognosis for the artery coronary disease. Use rubidium-82 generator makes it possible to estimate the myocardial perfusion with high sensitivity. Rubidium-82 generator may be used for investigation of brain, stomach, liver, kidneys.

2. Advantages of Rubidium-82 Generator

a) Ensures higher accuracy of the imaging (comparing with tallium-201, technetium-99m);

b) Makes possible to diagnose coronary vessels and to choose a strategy of treatment at early stage of disease. Radionuclide rubidium-82 may be used as a quantitative marker of viability or necrosis of myocardium tissue;

c) Reduces period of sequential imaging the investigation of the patient; makes it possible to perform sequential scanning of the investigational organ every 10 minutes;

d) Minimizes irradiation dose of the patient during investigation;

e) Makes possible to perform PET investigations in medical institutes without necessity to have expensive cyclotrons.

3. Manufacture of Radioisotope Rubidium-82

Rubidium-82 is a radiopharmaseutical preparation for positron-emission tomography. It is arisen in the generator through decay of mother radionuclide strontium-82. Radionuclide strontium-82 is on the adsorbent in the form of chloride. Strontium-82 chloride is eluted from the generator with the isotonic solution. In this case mother radionuclide strontium-82 remains on the adsorbent inside the generator.

4. Perspective of Rubidium-82 Generator Use

Now rubidium-82 generator does not manufacture both in Europe and Asia. Generator may be used in any medical institute equipped with positron-emission tomography both in Russia and Eurasian continent.

5. Technical Demands Compliance

All basic parameters of the radiopharmaceutical preparation eluate from the rubidium-82 generator (yield of rubidium-82, strontium-82 and strontium-85 breakthrough, sterility and apyrogenicity) and characteristic of generator as well follow all demands for goods and preparations of such type. It is ensured by the generator manufacturing technique.

6. Collaborators

The following collaborators took part in the development, manufacture, laboratory investigation and preclinical trials:
- FGU Central Roentgen Radiological Research Institute (Russia, Sanct-Petersburg)
- FSUE "Medradiopreparat Plant" of AES (Agency on Extreme Situations), Health Ministry of Russia (Russia, Moscow).

Person for contact: Dr. Boris L. Zhuikov Phone: +7(495)850-42-54


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